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Literature summary extracted from
- Activation of L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens by several amino acids and monocarboxylates (1989), J. Biochem., 106, 76-80.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.1.18 | 6-aminocaproate | - |
Agrobacterium tumefaciens |  |
| 1.4.1.18 | D,L-Homolysine | - |
Agrobacterium tumefaciens | |
| 1.4.1.18 | additional information | activiated by many amino acids | Agrobacterium tumefaciens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.1.18 | L-lysine + NAD+ + H2O | Agrobacterium tumefaciens | - |
alpha-aminoadipate delta-semialdehyde + NH3 + NADH | product is spontaneosly converted into delta1-piperideine-6-carboxylate | ? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.1.18 | Agrobacterium tumefaciens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.4.1.18 | - |
Agrobacterium tumefaciens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.1.18 | L-lysine + NAD+ + H2O | - |
Agrobacterium tumefaciens | alpha-aminoadipate delta-semialdehyde + NH3 + NADH | product is spontaneosly converted into delta1-piperideine-6-carboxylate | ? | |
| 1.4.1.18 | S-(beta-aminoethyl)-L-cysteine + NAD+ | 3% of the activity with L-lysine | Agrobacterium tumefaciens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.4.1.18 | dimer | after preincubation with NAD+ without L-lysine | Agrobacterium tumefaciens |
| 1.4.1.18 | tetramer | gel filtration and centrifugation in presence of L-lysine | Agrobacterium tumefaciens |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.4.1.18 | 5 | 7.5 | most stable | Agrobacterium tumefaciens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.1.18 | NAD+ | - |
Agrobacterium tumefaciens | |
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Release 2023.1 (January 2023)
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