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Literature summary extracted from

  • Scapin, G.; Cirilli, M.; Reddy, S.G.; Gao, Y.; Vederas, J.C.; Blanchard, J.S.
    Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase (1998), Biochemistry, 37, 3278-3285.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.1.16
-
 Corynebacterium glutamicum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.4.1.16 crystals of the ternary complex formed from the enzyme, NADP+ and the inhibitor (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid Corynebacterium glutamicum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.16 (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid
-
 Corynebacterium glutamicum

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.16 Corynebacterium glutamicum P04964
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.1.16
-
 Corynebacterium glutamicum

Reaction

EC Number Reaction Comment Organism Reaction ID
1.4.1.16 meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+ only amino acid dehydrogenase which stereospecifically oxidizes a D-stereocenter Corynebacterium glutamicum
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.1.16 L-2-amino-6-oxoheptanedioate + NH3 + NAD(P)H diaminopimelate synthesis is thermodynamically favoured Corynebacterium glutamicum meso-2,6-diaminoheptanedioate + H2O + NAD(P)+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.1.16 NADPH
-
 Corynebacterium glutamicum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.1.16 0.0042
-
 (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid reductive amination Corynebacterium glutamicum
1.4.1.16 0.023
-
 (2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid oxidative deamination at pH 7.8 Corynebacterium glutamicum