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Literature summary extracted from

  • Frerman, F.E.; Miziorko, H.M.; Beckmann, J.D.
    Enzyme-activated inhibitors, alternate substrates, and a dead end inhibitor of the general acyl-CoA dehydrogenase (1980), J. Biol. Chem., 255, 11192-11198.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.7 2,3-octadienoyl-CoA
-
 Sus scrofa
1.3.8.7 2-octenoyl-CoA
-
 Sus scrofa
1.3.8.7 2-octynoyl-CoA
-
 Sus scrofa
1.3.8.7 3-butynoyl-CoA concentration-dependent, progressive total inactivation, active site inhibitor Sus scrofa
1.3.8.7 octyl-CoA
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.8.7 0.0011
-
 octanoyl 3'-dephospho-CoA
-
 Sus scrofa
1.3.8.7 0.00221
-
 octanoyl-CoA
-
 Sus scrofa
1.3.8.7 0.00928
-
 octanoyl-1,N6-etheno-CoA
-
 Sus scrofa
1.3.8.7 0.107
-
 octanoyl-pantetheine
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.7 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.8.7 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.7 acyl-CoA + acceptor intermediary electron acceptor: 2,6-dichloroindophenol Sus scrofa 2,3-dehydroacyl-CoA + reduced acceptor
-
 ?
1.3.8.7 acyl-CoA + acceptor electron acceptor: phenazine methosulfate or electron transfer flavoprotein Sus scrofa 2,3-dehydroacyl-CoA + reduced acceptor
-
 ?
1.3.8.7 acyl-CoA + acceptor final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue Sus scrofa 2,3-dehydroacyl-CoA + reduced acceptor
-
 ?
1.3.8.7 n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol phenazine methosulfate substituted by electron transfer flavoprotein Sus scrofa 2-octenoyl-CoA + reduced acceptor
-
 ?
1.3.8.7 octanoyl 3'-dephospho-CoA + 2,6-dichloroindophenol
-
 Sus scrofa ?
-
 ?
1.3.8.7 octanoyl pantetheine + 2,6-dichloroindophenol
-
 Sus scrofa ?
-
 ?
1.3.8.7 octanoyl-1,N6-etheno-CoA + 2,6-dichloroindophenol
-
 Sus scrofa ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.8.7 0.235
-
 octanoyl-pantetheine general acyl-CoA dehydrogenase Sus scrofa
1.3.8.7 11.2
-
 octanoyl-CoA general acyl-CoA dehydrogenase Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.8.7 0.00073
-
 2,3-octadienoyl-CoA
-
 Sus scrofa
1.3.8.7 0.0034
-
 2-octenoyl-CoA
-
 Sus scrofa
1.3.8.7 0.0065
-
 2-octynoyl-CoA
-
 Sus scrofa
1.3.8.7 0.0134
-
 3-butynoyl-CoA
-
 Sus scrofa