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Literature summary extracted from

  • Gomes, B.; Fendrich, G.; Abeles, R.H.
    Mechanism of action of glutaryl-CoA and butyryl-CoA dehydrogenases. Purification of glutaryl-CoA dehydrogenase (1981), Biochemistry, 20, 1481-1490.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.1 3-Pentenoylpantetheine 0.62 mM, rapid irreversible inactivation Megasphaera elsdenii
1.3.8.6 3-Butynoylpantetheine irreversible Pseudomonas fluorescens
1.3.8.6 3-Pentynoylpantetheine irreversible Pseudomonas fluorescens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.8.6 0.0012 0.01 glutaryl-CoA
-
Pseudomonas fluorescens
1.3.8.6 2
-
Glutarylpantetheine
-
Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.1 Megasphaera elsdenii
-
-
-
1.3.8.6 Pseudomonas fluorescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.6
-
Pseudomonas fluorescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.6 glutaryl-CoA + acceptor acceptors: electron-transfer flavoprotein, phenylmethylsulfonyl fluoride, 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue Pseudomonas fluorescens crotonyl-CoA + CO2 + reduced acceptor
-
?
1.3.8.6 glutarylpantetheine + acceptor
-
Pseudomonas fluorescens crotonylpantetheine + reduced acceptor
-
?
1.3.8.6 additional information study on mechanism Pseudomonas fluorescens ?
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.6 FAD
-
Pseudomonas fluorescens