EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.5.2 | 2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | A77 1726, active metabolite of leflumonide | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.5.2 | Homo sapiens | - |
recombinant protein | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.5.2 | dihydroorotate + acceptor | - |
Homo sapiens | orotate + reduced acceptor | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.5.2 | 0.0002 | 0.0009 | 2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | competitive to ubiquinone, non-competitive to dihydroorotate, parent compound leflunomide has no inhibitory effect at concentrations up to 0.001 mM | Homo sapiens |