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Literature summary extracted from

  • Davis, J.P.; Cain, G.A.; Pitts, W.J.; Magolda, R.L.; Copeland, R.A.
    The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase (1996), Biochemistry, 35, 1270-1273.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.2 2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide A77 1726, active metabolite of leflumonide Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.2 Homo sapiens
-
recombinant protein
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.2 dihydroorotate + acceptor
-
Homo sapiens orotate + reduced acceptor
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.5.2 0.0002 0.0009 2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide competitive to ubiquinone, non-competitive to dihydroorotate, parent compound leflunomide has no inhibitory effect at concentrations up to 0.001 mM Homo sapiens