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Literature summary extracted from

  • Forman, H.J.; Kennedy, J.
    Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme (1978), Arch. Biochem. Biophys., 191, 23-31.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.2 1,10-phenanthroline
-
 Rattus norvegicus
1.3.5.2 additional information not: bathophenathroline, sulfonate, ethylendiaminetetraacetate, cyanide, azide Rattus norvegicus
1.3.5.2 Thenoyltrifluoroacetone
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.5.2 0.0058
-
 2,6-dihydrophenolindophenol
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.2 mitochondrion inner membrane Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.5.2 Iron iron-zinc protein Rattus norvegicus
1.3.5.2 Zinc iron-zinc protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.2 dihydroorotate + acceptor Rattus norvegicus fourth step in pyrimidine biosynthesis orotate + reduced acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.2 dihydroorotate + acceptor acceptor: 2,6-dichlorophenolindophenol Rattus norvegicus orotate + reduced acceptor
-
 ?
1.3.5.2 dihydroorotate + acceptor acceptors: e.g. phenazine methosulfate Rattus norvegicus orotate + reduced acceptor
-
 ?
1.3.5.2 dihydroorotate + acceptor acceptor: ubiquinone Rattus norvegicus orotate + reduced acceptor
-
 ?
1.3.5.2 dihydroorotate + acceptor acceptor: oxygen, slowly Rattus norvegicus orotate + reduced acceptor
-
 ?
1.3.5.2 dihydroorotate + acceptor fourth step in pyrimidine biosynthesis Rattus norvegicus orotate + reduced acceptor
-
 ?
1.3.5.2 L-dihydroorotate + 2,6-dihydrophenolindophenol
-
 Rattus norvegicus orotate + reduced 2,6-dihydrophenolindophenol
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.5.2 7.1
-
 dihydroorotate + 2,6-dichlorophenolindophenol Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.2 FMN does not contain FMN Rattus norvegicus
1.3.5.2 additional information enzyme does not contain FAD, FMN, covalently bound flavin or ubiquinone Rattus norvegicus