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Literature summary extracted from

  • Ikeda, Y.; Tanaka, K.
    Isovaleryl-CoA dehydrogenase from rat liver (1988), Methods Enzymol., 166, 374-389.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.8.4 (methylenecyclopropyl)acetyl-CoA completely inhibits at 0.01 mM Rattus norvegicus
1.3.8.4 3-methylcrotonyl-CoA
-
Rattus norvegicus
1.3.8.4 Ag+ completely inhibits at 0.01 mM Rattus norvegicus
1.3.8.4 Cu2+ completely inhibits at 0.01 mM Rattus norvegicus
1.3.8.4 Hg2+ completely inhibits at 0.1 mM Rattus norvegicus
1.3.8.4 Methylmercury iodide completely inhibits at a concentration of 0.1 mM Rattus norvegicus
1.3.8.4 N-ethylmaleimide completely inhibits at a concentration of 2 mM Rattus norvegicus
1.3.8.4 p-hydroxymercuribenzoate completely inhibits at a concentration of 0.01 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.8.4 0.0167 0.4 n-valeryl-CoA
-
Rattus norvegicus
1.3.8.4 0.033
-
isovaleryl-CoA with phenazine methosulfate as an artificial electron acceptor Rattus norvegicus
1.3.8.4 0.4
-
n-valeryl-CoA
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.8.4 mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.8.4 43000
-
4 * 43000, SDS-PAGE Rattus norvegicus
1.3.8.4 175000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.8.4 isovaleryl-CoA + acceptor Rattus norvegicus electron acceptor: electron-transfer flavoprotein serves as a natural electron acceptor for the enzyme with isovaleryl-CoA as substrate 3-methylcrotonyl-CoA + reduced acceptor
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.4 using sonication, ammonium sulfate treatment and column chromatography on DEAE-Sephadex A-50, hydroxylapatite, Matrex Gel Blue A and BioGel A-0.5 m Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.8.4 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.8.4 0.086
-
substrate: n-butyryl-CoA Rattus norvegicus
1.3.8.4 0.832
-
substrate: n-valeryl-CoA Rattus norvegicus
1.3.8.4 2.68
-
substrate: isovaleryl-CoA Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.4 isovaleryl-CoA + acceptor isovaleryl-CoA is the preferred substrate Rattus norvegicus 3-methylcrotonyl-CoA + reduced acceptor
-
?
1.3.8.4 isovaleryl-CoA + acceptor acceptors: electron-transfer flavoprotein, phenazine methosulfate Rattus norvegicus 3-methylcrotonyl-CoA + reduced acceptor
-
?
1.3.8.4 isovaleryl-CoA + acceptor electron acceptor: electron-transfer flavoprotein serves as a natural electron acceptor for the enzyme with isovaleryl-CoA as substrate Rattus norvegicus 3-methylcrotonyl-CoA + reduced acceptor
-
?
1.3.8.4 n-valeryl-CoA + acceptor
-
Rattus norvegicus pent-2-enoyl-CoA + reduced acceptor
-
?

Subunits

EC Number Subunits Comment Organism
1.3.8.4 tetramer 4 * 43000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.8.4 8
-
isovaleryl-CoA + phenazine methosulfate Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.4 FAD the enzyme contains FAD as a prosthetic group, 0.6 mol FAD per mol of subunit Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.8.4 0.02
-
3-methylcrotonyl-CoA
-
Rattus norvegicus