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Literature summary extracted from

  • Armson, A.; Grubb, W.B.; Mendis, A.H.W.
    The effect of electron transport (ET) inhibitors and thiabendazole on the fumarate reductase (FR) and succinate dehydrogenase (SDH) of Strongyloides ratti infective (L3) larvae (1995), Int. J. Parasitol., 25, 261-263.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 2-thenoyltrifluoracetone EC50 fumarate reductase 0.026 mM, EC50 succinate dehydrogenase 0.028 mM Strongyloides ratti
1.3.5.1 rotenone inhibits fumarate reductase, not succinate dehydrogenase Strongyloides ratti
1.3.5.1 sodium fumarate EC50 fumarate reductase 0.6 mM and EC50 succinate dehydrogenase 4.8 mM Strongyloides ratti
1.3.5.1 sodium malonate EC50 fumarate reductase 19 mM and EC50 succinate dehydrogenase 0.68 mM Strongyloides ratti
1.3.5.1 thiabendazole EC50 fumarate reductase 0.46 mM and EC50 succinate dehydrogenase 1 mM Strongyloides ratti

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 mitochondrion
-
 Strongyloides ratti 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Strongyloides ratti
-
 infective larvae
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 fumarate + electron donor
-
 Strongyloides ratti succinate + oxidized donor
-
 ?
1.3.5.1 additional information catalytic mechanism Strongyloides ratti ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.1 cytochrome c
-
 Strongyloides ratti
1.3.5.1 heme
-
 Strongyloides ratti