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Literature summary extracted from

  • Amino, H.; Wang, H.; Hirawake, H.; Saruta, F.; Mizuchi, D.; Mineki, R.; Shindo, N.; Murayama, K.; Takamiya, S.; Aoki, T.; Kojima, S.; Kita, K.
    Stage-specific isoforms of Ascaris suum complex II: the fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit (2000), Mol. Biochem. Parasitol., 106, 63-76.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.5.1 cDNA of iron-sulfur subunit Ascaris suum
1.3.5.1 cDNA of iron-sulfur subunit Caenorhabditis elegans
1.3.5.1 cloning of the complete cDNAs for the iron-sulfur protein of complex II Caenorhabditis elegans
1.3.5.1 cloning of the complete cDNAs for the iron-sulfur protein of complex II from anaerobic adult Ascaris suum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 mitochondrion
-
 Ascaris suum 5739
-
1.3.5.1 mitochondrion of the adult parasitic nematode and of free living second stage larvae Ascaris suum 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 additional information Ascaris suum complex II of adult organism muscle exhibits high fumarate reductase activity and plays a key role in anaerobic electron-transport during adaptation to their microaerobic habitat, in contrast larval complex II shows a much lower fumarate reductase activity than the adult enzyme and functions as succinate dehydrogenase in aerobic respiration ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Ascaris suum
-
-
-
1.3.5.1 Ascaris suum
-
 succinate dehydrogenase
-
1.3.5.1 Ascaris suum
-
 fumarate reductase
-
1.3.5.1 Caenorhabditis elegans
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.5.1 of larval and adult complex II, using DEAE-cellulofine column chromatography in the presence of 0.1% w/v sucrose monolaurate Ascaris suum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.5.1 muscle
-
 Ascaris suum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 additional information complex II of adult organism muscle exhibits high fumarate reductase activity and plays a key role in anaerobic electron-transport during adaptation to their microaerobic habitat, in contrast larval complex II shows a much lower fumarate reductase activity than the adult enzyme and functions as succinate dehydrogenase in aerobic respiration Ascaris suum ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.5.1 ? two different stage specific forms of complex II (EC 1.3.5.1) share a comme iron-sulfur subunit Ascaris suum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.1 cytochrome b
-
 Ascaris suum
1.3.5.1 additional information the fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit, at least the flavoprotein subunit and the small subunit of cytochrome b of the larval complex II differ from those of adult Ascaris suum
1.3.5.1 additional information the enzyme contains iron-sulfur centers Ascaris suum