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Literature summary extracted from

  • Suzuki, H.; Yamada, J.; Watanabe, T.; Suga, T.
    Compartmentation of dicarboxylic acid beta-oxidation in rat liver: importance of peroxisomes in the metabolism of dicarboxylic acids (1989), Biochim. Biophys. Acta, 990, 25-30.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.6 additional information
-
 additional information overview: Km of several monocarboxylic and dicarboxylic acyl-CoA as substrates Rattus norvegicus
1.3.8.1 0.0112
-
 butyryl-CoA
-
 Rattus norvegicus
1.3.8.1 0.034
-
 hexanoyl-CoA
-
 Rattus norvegicus
1.3.8.8 0.00571
-
 dodecanoyl-CoA
-
 Rattus norvegicus
1.3.8.8 0.0111
-
 palmitoyl-CoA
-
 Rattus norvegicus
1.3.8.8 0.0112
-
 stearoyl-CoA
-
 Rattus norvegicus
1.3.8.8 0.0125
-
 tetradecanoyl-CoA
-
 Rattus norvegicus
1.3.8.8 0.019
-
 decanoyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.6 peroxisome
-
 Rattus norvegicus 5777
-
1.3.8.8 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.6 acyl-CoA + O2 Rattus norvegicus involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
1.3.3.6 acyl-CoA + O2 Rattus norvegicus beta-oxidation of dicarboxylic acid-CoAs in rat liver is carried out exclusively in peroxisomes trans-2,3-dehydroacyl-CoA + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.6 Rattus norvegicus
-
 inducible by growth on di-(2-ethylhexyl)phthalate
-
1.3.8.1 Rattus norvegicus
-
-
-
1.3.8.8 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.8.8
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.3.3.6 acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 inducible by growth on di-(2-ethylhexyl)phthalate Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.6 liver
-
 Rattus norvegicus
-
1.3.8.1 liver
-
 Rattus norvegicus
-
1.3.8.8 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.6 acyl-CoA + O2 C4-C18 monocarboxylic acid-CoA Rattus norvegicus trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
1.3.3.6 acyl-CoA + O2 C6-C16 dicarboxylic-CoA Rattus norvegicus trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
1.3.3.6 acyl-CoA + O2 involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively Rattus norvegicus trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
1.3.3.6 acyl-CoA + O2 beta-oxidation of dicarboxylic acid-CoAs in rat liver is carried out exclusively in peroxisomes Rattus norvegicus trans-2,3-dehydroacyl-CoA + H2O2
-
 ?
1.3.3.6 dicarboxylic acid-CoAs with 6-16 carbon atoms + O2
-
 Rattus norvegicus ?
-
 ?
1.3.8.1 butyryl-CoA + electron acceptor no activity towards dicarboxylic-CoAs Rattus norvegicus 2-butenoyl-CoA + reduced acceptor
-
 ?
1.3.8.8 decanoyl-CoA + phenazine methosulfate
-
 Rattus norvegicus (2E)-2-decenoyl-CoA + reduced phenazine methosulfate
-
 ?
1.3.8.8 dodecanoyl-CoA + phenazine methosulfate
-
 Rattus norvegicus (2E)-2-dodecenoyl-CoA + reduced phenazine methosulfate
-
 ?
1.3.8.8 palmitoyl-CoA + phenazine methosulfate
-
 Rattus norvegicus 2-hexadecenoyl-CoA + reduced phenazine methosulfate
-
 ?
1.3.8.8 stearoyl-CoA + phenazine methosulfate
-
 Rattus norvegicus 2-octadecenoyl-CoA + reduced phenazine methosulfate
-
 ?
1.3.8.8 tetradecanoyl-CoA + phenazine methosulfate
-
 Rattus norvegicus 2-tetradecenoyl-CoA + reduced phenazine methosulfate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.3.6 FAD
-
 Rattus norvegicus