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Literature summary extracted from

  • Birchfield, N.B.; Latli, B.; Casida, J.E.
    Human protoporphyrinogen oxidase: Relation between the herbicide binding site and the flavin cofactor (1998), Biochemistry, 37, 6905-6910.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.4 in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.4 acifluorfen competitive Homo sapiens
1.3.3.4 diphenylene iodonium 50% inhibition at 0.1 mM Homo sapiens
1.3.3.4 additional information inhibited by diphenylether herbicides; inhibited by tetrahydrophtalimide Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen-IX + 3 O2 Homo sapiens penultimate step of heme and chlorophyll biosynthesis protoporphyrin-IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.4 cloned enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen-IX + 3 O2
-
 Homo sapiens protoporphyrin-IX + 3 H2O2
-
 ?
1.3.3.4 protoporphyrinogen-IX + 3 O2 penultimate step of heme and chlorophyll biosynthesis Homo sapiens protoporphyrin-IX + 3 H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.3.4 FAD one noncovalently bound FAD per dimer Homo sapiens