Literature summary extracted from

Ferreira, G.C.; Andrew, T.L.; Karr, S.W.; Dailey, H.A.
Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex (1988), J. Biol. Chem., 263, 3835-3839.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.3.4	bilirubin	competitive	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.3.3.4	mitochondrion	lipid bilayer of inner membrane	Mus musculus	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.3.3.4	protoporphyrinogen-IX + 3 O2	Mus musculus	penultimate step of heme and chlorophyll biosynthesis	protoporphyrin-IX + 3 H2O2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.3.4	Mus musculus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.3.3.4	-	Mus musculus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.3.4	liver	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.3.4	protoporphyrinogen-IX + 3 O2	-	Mus musculus	protoporphyrin-IX + 3 H2O2	-	?
1.3.3.4	protoporphyrinogen-IX + 3 O2	penultimate step of heme and chlorophyll biosynthesis	Mus musculus	protoporphyrin-IX + 3 H2O2	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.3.3.4	0.025	-	bilirubin	-	Mus musculus

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Release 2023.1 (January 2023)