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Literature summary extracted from
- The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria (1976), J. Biol. Chem., 251, 3730-3733.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 1.3.3.4 | stable on dialysis | Rattus norvegicus |
| 1.3.3.4 | stable on dialysis | Saccharomyces cerevisiae |
| 1.3.3.4 | stable on freezing and thawing | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.3.4 | iodoacetamide | - |
Rattus norvegicus |  |
| 1.3.3.4 | iodoacetamide | - |
Saccharomyces cerevisiae | |
| 1.3.3.4 | additional information | - |
Homo sapiens | |
| 1.3.3.4 | additional information | inhibited by high salt concentrations | Rattus norvegicus | |
| 1.3.3.4 | additional information | inhibited by high salt concentrations | Saccharomyces cerevisiae | |
| 1.3.3.4 | p-hydroxymercuribenzoate | more than 90% inhibition at 0.5 mM | Rattus norvegicus | |
| 1.3.3.4 | p-hydroxymercuribenzoate | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.3.4 | 0.011 | - |
protoporphyrinogen-IX | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.3.3.4 | mitochondrion | - |
Homo sapiens | 5739 | - |
| 1.3.3.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 1.3.3.4 | mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.3.4 | additional information | no metal ions required | Rattus norvegicus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.3.3.4 | 33000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | Homo sapiens | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | Rattus norvegicus | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | Saccharomyces cerevisiae | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.3.4 | Homo sapiens | - |
- |
- |
| 1.3.3.4 | Rattus norvegicus | - |
- |
- |
| 1.3.3.4 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.3.3.4 | partial | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.3.3.4 | fibroblast | - |
Homo sapiens | - |
| 1.3.3.4 | liver | - |
Homo sapiens | - |
| 1.3.3.4 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.3.3.4 | 0.0087 | - |
partially purified enzyme | Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.3.3.4 | -20°C, stable for several months | Rattus norvegicus |
| 1.3.3.4 | 0-4°C, stable for 1 week | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.3.4 | mesoporphyrinogen-IX + 3 O2 | - |
Homo sapiens | mesoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | mesoporphyrinogen-IX + 3 O2 | - |
Saccharomyces cerevisiae | mesoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | mesoporphyrinogen-IX + 3 O2 | 10% of the rate of protoporphyrinogen-IX | Rattus norvegicus | mesoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | - |
Homo sapiens | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | - |
Rattus norvegicus | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | - |
Saccharomyces cerevisiae | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Homo sapiens | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Rattus norvegicus | protoporphyrin-IX + 3 H2O2 | - |
? | |
| 1.3.3.4 | protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Saccharomyces cerevisiae | protoporphyrin-IX + 3 H2O2 | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.3.3.4 | 45 | - |
inactivated above 45°C, half maximal activity after 100 min | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.3.3.4 | 8.6 | 8.8 | - |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.3.3.4 | 7 | 10.5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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