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Literature summary extracted from

  • Tait, G.H.
    Coproporphyrinogenase activities in extracts of Rhodopseudomonas spheroids and Chromatium strain D (1972), Biochem. J., 128, 1159-1169.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.3.3 L-methionine maximal activity at 0.5 mM Cereibacter sphaeroides
1.3.3.3 S-adenosyl-L-methionine can replace NADP+-NADH in anaerobic reaction Chromatium sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.3 1,10-phenanthroline 90% inhibition of anaerobic reaction at 0.17 mM Cereibacter sphaeroides
1.3.3.3 1,4-Naphthoquinone 61% inhibition at 0.015 mM Cereibacter sphaeroides
1.3.3.3 2,2-bipyridyl 77% inhibition of anaerobic reaction at 1.5 mM Cereibacter sphaeroides
1.3.3.3 2,4-dinitrophenol 95% inhibition of anaerobic reaction at 1 mM Cereibacter sphaeroides
1.3.3.3 FAD 95% inhibition of anaerobic reaction at 0.03 mM Cereibacter sphaeroides
1.3.3.3 FMN 95% inhibition of anaerobic reaction at 0.03 mM Cereibacter sphaeroides
1.3.3.3 riboflavin 95% inhibition of anaerobic reaction at 0.03 mM Cereibacter sphaeroides
1.3.3.3 S-adenosylethionine marked inhibition of anaerobic reaction Cereibacter sphaeroides
1.3.3.3 S-adenosylhomocysteine marked inhibition of anaerobic reaction Cereibacter sphaeroides

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.3 0.03 0.05 Coproporphyrinogen-III
-
 Cereibacter sphaeroides

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.3.3 44000
-
 gel filtration Cereibacter sphaeroides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + ? Cereibacter sphaeroides anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+ protoporphyrinogen-IX + ?
-
 ?
1.3.3.3 coproporphyrinogen-III + ? Chromatium sp. anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+ protoporphyrinogen-IX + ?
-
 ?
1.3.3.3 coproporphyrinogen-III + ? Chromatium sp. D anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+ protoporphyrinogen-IX + ?
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Cereibacter sphaeroides
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Chromatium sp.
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Chromatium sp. D
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Cereibacter sphaeroides
-
-
-
1.3.3.3 Chromatium sp.
-
-
-
1.3.3.3 Chromatium sp. D
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.3 partial Cereibacter sphaeroides

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 cell culture
-
 Cereibacter sphaeroides
-
1.3.3.3 cell culture
-
 Chromatium sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + ? anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+ Cereibacter sphaeroides protoporphyrinogen-IX + ?
-
 ?
1.3.3.3 coproporphyrinogen-III + ? anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+ Chromatium sp. protoporphyrinogen-IX + ?
-
 ?
1.3.3.3 coproporphyrinogen-III + ? anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+ Chromatium sp. D protoporphyrinogen-IX + ?
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Cereibacter sphaeroides protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Chromatium sp. protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Chromatium sp. D protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.3.3 7.3
-
 aerobic activity Cereibacter sphaeroides
1.3.3.3 8.5
-
 anaerobic reaction Cereibacter sphaeroides

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.3.3 ATP
-
 Chromatium sp.
1.3.3.3 ATP strictly required for anaerobic enzyme Cereibacter sphaeroides
1.3.3.3 NADP+ only anaerobic enzyme, maximum activity together with NADH Cereibacter sphaeroides
1.3.3.3 NADP+ only anaerobic enzyme, maximum activity together with NADH Chromatium sp.