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Literature summary extracted from

  • Elder, G.H.; Evans, J.O.
    A radiochemical method for the measurement of coproporphyrinogen oxidase and the utilization of substrates other than coproporphyrinogen III by the enzyme from rat liver (1978), Biochem. J., 169, 205-214.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.3 Coproporphyrin I 70% inhibition at 0.0195 mM Rattus sp.
1.3.3.3 Coproporphyrin II 61% inhibition at 0.0206 mM Rattus sp.
1.3.3.3 coproporphyrin III 52% inhibition at 0.0194 mM Rattus sp.
1.3.3.3 Coproporphyrin IV 30% inhibition at 0.0196 mM Rattus sp.
1.3.3.3 Harderoporphyrin 27% inhibition at 0.02 mM Rattus sp.
1.3.3.3 Pentacarboxylate porphyrin III 10% inhibition at 0.0198 mM Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.3 0.00012
-
 Coproporphyrinogen-III
-
 Rattus sp.
1.3.3.3 0.0009
-
 coproporphyrinogen IV
-
 Rattus sp.
1.3.3.3 0.0016
-
 Harderoporphyrinogen
-
 Rattus sp.
1.3.3.3 0.029
-
 pentacarboxylate porphyrinogen III
-
 Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.3 mitochondrion
-
 Rattus sp. 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Rattus sp.
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-IV + O2 Rattus sp.
-
 protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 harderoporphyrinogen + O2 Rattus sp.
-
 protoporphyrinogen IX + CO2 + H2O2
-
 ?
1.3.3.3 pentacarboxylate porphyrinogen III + O2 Rattus sp. half of the activity compared to coproporphyrinogen oxidase-III dehydroisocoproporphyrinogen + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Rattus sp. protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-IV + O2
-
 Rattus sp. protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 harderoporphyrinogen + O2
-
 Rattus sp. protoporphyrinogen IX + CO2 + H2O2
-
 ?
1.3.3.3 harderoporphyrinogen + O2 + H+
-
 Rattus sp. protoporphyrinogen IX + CO2 + H2O2
-
 r
1.3.3.3 pentacarboxylate porphyrinogen III + O2 half of the activity compared to coproporphyrinogen oxidase-III Rattus sp. dehydroisocoproporphyrinogen + CO2
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.3.3 0.0076
-
 Coproporphyrinogen-III competitive inhibition Rattus sp.