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Literature summary extracted from

  • Yoshinaga, T.; Sano, S.
    Coproporphyrinogen oxidase. II. Reaction mechanism and role of tyrosine residues on the activity (1980), J. Biol. Chem., 255, 4727-4731.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.3.3 Phospholipids effective in decreasing the amount of intermediate accumulation, oxidation of 2,4-bis(beta-hydroxypropionic acid) deuteroporphyrinogen IX not activated Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.3 Tetranitromethane 60% decrease of Vmax at 1.6 mol modified tyrosine per mol enzyme, Km not affected Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.3 0.039
-
 Harderoporphyrinogen presence of L-alpha-phosphatidylethanolamine Bos taurus
1.3.3.3 0.044
-
 Harderoporphyrinogen
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Bos taurus
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 harderoporphyrinogen + O2 Bos taurus 30% higher activity compared to coproporphyrinogen-III protoporphyrinogen IX + CO2 + H2O2
-
 ?
1.3.3.3 isoharderoporphyrinogen + O2 Bos taurus 3% of the activity compared to coproporphyrinogen-III protoporphyrinogen IX + CO2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 2,4-bis-(beta-hydroxypropionic acid) deuteroporphyrinogen IX + O2 one sixth of the rate compared to coproporhyrinogen-III Bos taurus protoporphyrinogen IX + CO2
-
 ?
1.3.3.3 2-beta-hydroxypropionic acid-4-propionic acid deuteroporphyrinogen IX + O2 80% of the activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2
-
 ?
1.3.3.3 2-propionic acid-4-beta-hydroxypropionic acid deuteroporphyrinogen IX + O2 8% of the activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Bos taurus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 harderoporphyrinogen + O2 30% higher activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2 + H2O2
-
 ?
1.3.3.3 isoharderoporphyrinogen + O2 3% of the activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2 + H2O2
-
 ?