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Literature summary extracted from

  • Bogard, M.; Camadro, J.M.; Labbe, P.
    Purification and properties of mouse liver coproporphyrinogen oxidase (1989), Eur. J. Biochem., 181, 417-421.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.3.3 lecithin lowers Km, increases Vmax Mus musculus
1.3.3.3 Non-ionic detergents
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.3 5,5-dithiobis(2-nitrobenzoic acid) significant inhibition, IC50: 0.05 mM Mus musculus
1.3.3.3 sodium cholate
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.3 0.1
-
 Coproporphyrinogen-III presence of activating lecithin Mus musculus
1.3.3.3 0.32
-
 Coproporphyrinogen-III
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.3.3 35000
-
 2 * 35000, SDS-PAGE Mus musculus
1.3.3.3 70000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Mus musculus 6th enzyme in heme biosynthetic pathway protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.3 to homogeneity, chromatography steps Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.3.3 0.06
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ sixths enzyme in heme biosynthetic pathway Mus musculus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ 6th enzyme in heme biosynthetic pathway Mus musculus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.3.3 dimer 2 * 35000, SDS-PAGE Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.3.3 0.05
-
 significant inhibition, IC50: 0.05 mM Mus musculus 5,5-dithiobis(2-nitrobenzoic acid)