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Literature summary extracted from

  • Sorianello, E.M.; Mazzetti, M.B.
    Function and structure of rat hepatic coproporphyrinogen oxidase (2000), Comp. Biochem. Physiol. B, 127, 155-164.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.3.3 L-alpha-phosphatidylcholine activation in sonicated mitochondria up to 150% Rattus sp.
1.3.3.3 phosphatidate activation in sonicated mitochondria up to 150% Rattus sp.
1.3.3.3 phosphatidyl glycerol activation in intact and sonicated mitochondria up to 135% Rattus sp.
1.3.3.3 Triton X-100 concentration-dependent activation up to 2.8fold Rattus sp.
1.3.3.3 Tween 20 concentration-dependent activation up to 152% Rattus sp.

General Stability

EC Number General Stability Organism
1.3.3.3 purified enzyme rather unstable, 2 days Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.3 diethyl dicarbonate concentration-dependent inhibition, complete inactivation at 50 mM Rattus sp.
1.3.3.3 KCl 70% inhibition at 1 M Rattus sp.
1.3.3.3 N-bromosuccinimide concentration-dependent inhibition, complete inactivation at 50 mM Rattus sp.
1.3.3.3 NaCl 60% inhibition at 1 M Rattus sp.
1.3.3.3 Phenylglyoxal concentration-dependent inhibition, complete inactivation at 50 mM Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.3 mitochondrion located within intermembrane space Rattus sp. 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.3.3 38000
-
 2 * 38000, SDS-PAGE Rattus sp.
1.3.3.3 77000
-
 minimum catalytic activity, also aggregation to 154000 kDa catalytic activity, gel filtration Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ Rattus sp. 6th enzyme in heme biosynthetic pathway protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Rattus sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.3 to homogeneity, chromatography techniques Rattus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 liver
-
 Rattus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.3.3 0.009
-
-
 Rattus sp.

Storage Stability

EC Number Storage Stability Organism
1.3.3.3 -20°C, 30-65% ammonium sulfate precipitate, 2 months Rattus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ sixths enzyme in heme biosynthetic pathway Rattus sp. protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+ 6th enzyme in heme biosynthetic pathway Rattus sp. protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.3.3 dimer 2 * 38000, SDS-PAGE Rattus sp.

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 CPGox
-
 Rattus sp.