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Literature summary extracted from

  • Chen, M.; Bennedsen, M.; Zhai, L.; Kharazmi, A.
    Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites (2001), APMIS, 109, 801-808.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.6 medicine might serve as target for anti-Leishmania drugs Leishmania donovani
1.3.1.6 medicine might serve as target for anti-Leishmania drugs Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.6 Cu2+
-
 Leishmania donovani
1.3.1.6 Cu2+
-
 Leishmania major
1.3.1.6 malonate
-
 Leishmania donovani
1.3.1.6 Zn2+ strong inhibitor Leishmania donovani
1.3.1.6 Zn2+ strong inhibitor Leishmania major

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.6 membrane
-
 Leishmania donovani 16020
-
1.3.1.6 mitochondrion
-
 Leishmania major 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.6 65000
-
-
 Leishmania donovani

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ Leishmania donovani component of respiratory chain succinate + NAD+
-
 ?
1.3.1.6 fumarate + NADH + H+ Leishmania major component of respiratory chain succinate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Leishmania donovani
-
-
-
1.3.1.6 Leishmania major
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.6
-
 Leishmania donovani

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.6 amastigote
-
 Leishmania donovani
-
1.3.1.6 promastigote
-
 Leishmania donovani
-
1.3.1.6 promastigote
-
 Leishmania major
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.6 2189
-
 purified enzyme from promastigotes Leishmania donovani

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+
-
 Leishmania donovani succinate + NAD+
-
 ?
1.3.1.6 fumarate + NADH + H+
-
 Leishmania major succinate + NAD+
-
 ?
1.3.1.6 fumarate + NADH + H+ component of respiratory chain Leishmania donovani succinate + NAD+
-
 ?
1.3.1.6 fumarate + NADH + H+ component of respiratory chain Leishmania major succinate + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.6 NADH
-
 Leishmania donovani
1.3.1.6 NADH
-
 Leishmania major