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Literature summary extracted from

  • Gaines, C.G.; Byng, G.S.; Whitaker, R.J.; Jensen, R.A.
    L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes (1982), Planta, 156, 233-240.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.78 D-tyrosine
-
 Nicotiana sylvestris
1.3.1.78 L-tyrosine
-
 Nicotiana sylvestris
1.3.1.78 m-Fluoro-DL-tyrosine
-
 Nicotiana sylvestris
1.3.1.78 N-Acetyl-DL-tyrosine
-
 Nicotiana sylvestris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.78 0.0087
-
 NADP+
-
 Nicotiana sylvestris
1.3.1.78 0.1
-
 L-arogenate
-
 Nicotiana sylvestris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.78 L-arogenate + NAD+ Nicotiana sylvestris exclusive metabolic route to tyrosine L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ Nicotiana sylvestris i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine L-tyrosine + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.78 Nicotiana sylvestris
-
 wood tobacco
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.78 L-arogenate + NAD(P)+
-
 Nicotiana sylvestris L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ exclusive metabolic route to tyrosine Nicotiana sylvestris L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine Nicotiana sylvestris L-tyrosine + NADH + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.78 NAD+ not Nicotiana sylvestris
1.3.1.78 NADP+
-
 Nicotiana sylvestris