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Literature summary extracted from

  • Cinti, D.L.; Nagi, M.N.; Cook, L.; White, R.E.
    Evidence for a second microsomal trans-2-enoyl coenzyme A reductase in rat liver. NADPH-specific short chain reductase (1982), J. Biol. Chem., 257, 14333-14340.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.8 microsome
-
 Rattus norvegicus
-
-
1.3.1.38 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.38 crotonyl-CoA + NADPH Rattus norvegicus i.e. trans-2-butenoyl-CoA butanoyl-CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.8 Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-
1.3.1.38 Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 not yet possible
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.8 liver
-
 Rattus norvegicus
-
1.3.1.38 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.38 0.05
-
 substrate trans-hexenoyl-CoA Rattus norvegicus
1.3.1.38 0.065
-
 substrate trans-hexenoyl-CoA Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.8 2-trans-hexenoyl-CoA + NAD(P)H
-
 Rattus norvegicus hexanoyl-CoA + NADP+
-
 ?
1.3.1.8 crotonyl-CoA + NAD(P)H
-
 Rattus norvegicus butanoyl-CoA + NADP+
-
 ?
1.3.1.8 additional information NADPH specific trans-enoyl-CoA reductases isolated from rat liver microsomes and mitochondria impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?
1.3.1.38 crotonyl-CoA + NADPH
-
 Rattus norvegicus butanoyl-CoA + NADP+
-
 ?
1.3.1.38 crotonyl-CoA + NADPH i.e. trans-2-butenoyl-CoA Rattus norvegicus butanoyl-CoA + NADP+
-
 ?
1.3.1.38 additional information NADPH-specific trans-enoyl-CoA reductases from rat liver miochondria and microsomes impossible to classify according to EC 1.3.1.8 or EC 1.3.1.38 because no cis-isomers of 2-enoyl-CoA have been tested as substrates Rattus norvegicus ?
-
 ?
1.3.1.38 trans-2-hexenoyl-CoA + NADPH
-
 Rattus norvegicus hexanoyl-CoA + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.8 2-trans-enoyl-CoA reductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.8 NADPH inactive with NADH Rattus norvegicus
1.3.1.38 NADPH
-
 Rattus norvegicus