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Literature summary extracted from

  • Pugh, E.L.; Kates, M.
    Characterization of a membrane-bound phospholipid desaturase system of candida lipolytica (1975), Biochim. Biophys. Acta, 380, 442-453.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.19.22 Triton X-100 at an optimal concentration of 0.1% Triton X-100, the detergent increases the rate of desaturation about three fold Yarrowia lipolytica

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.22 cyanide the enzyme inhibited by cyanide but not by carbon monoxide, indicating that it required cytochrome b5 Yarrowia lipolytica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.19.22 0.25
-
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
-
Yarrowia lipolytica
1.14.19.22 0.25
-
1-acyl-2-oleoyl-sn-glycero-3-phosphorylcholine pH 7.4, 37°C Yarrowia lipolytica
1.14.19.22 0.95
-
1,2-di-oleoyl-sn-glycero-3-phosphorylcholine
-
Yarrowia lipolytica
1.14.19.22 0.95
-
1,2-di-oleoyl-sn-glycero-3-phosphorylcholine pH 7.4, 37°C Yarrowia lipolytica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.22 microsome
-
Yarrowia lipolytica
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.22 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+ Yarrowia lipolytica
-
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.22 Yarrowia lipolytica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.22 1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+ desaturation takes place at both position-1 and position-2. The distearoyl or dielaidoyl phosphatidylcholines are not desaturated Yarrowia lipolytica 1,2-di-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O
-
?
1.14.19.22 1,2-di-oleoyl-sn-glycero-3-phosphorylcholine + O2 + ?
-
Yarrowia lipolytica ?
-
?
1.14.19.22 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2 + H+
-
Yarrowia lipolytica 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
-
?
1.14.19.22 1-acyl-2-oleoyl-sn-glycero-3-phosphorylcholine + 2 ferrocytochrome b5 + O2 + 2 H+
-
Yarrowia lipolytica 1-acyl-2-linoleoyl-sn-glycero-3-phosphorylcholine + 2 ferricytochrome b5 + 2 H2O
-
?
1.14.19.22 additional information not: di-oleoyl phosphatidylcholine, dielaidoyl phosphatidylcholine Yarrowia lipolytica ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.22 oleoyl-CoA desaturase incorrect Yarrowia lipolytica

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.22 cytochrome b5 required Yarrowia lipolytica
1.14.19.22 NAD+
-
Yarrowia lipolytica