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Literature summary extracted from

  • Scapin, G.; Reddy, S.G.; Zheng, R.; Blanchard, J.S.
    Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate (1997), Biochemistry, 36, 15081-15088.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.17.1.8 medicine design and evaluation of dihydropicolinate reductase inhibitors as broad spectrum antibiotics and herbicides Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.17.1.8 R-factor 21.4%, three-dimensional structure analysis , homotetramer with 3 molecules of NADH, 3 molecules of inhibitor 2,6-pyridinedicarboxylic acid, 1 phosphate ion and 186 water molecules per asymmetric unit in the model Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.8 2,6-pyridinedicarboxylic acid
-
 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.17.1.8 12000
-
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H Escherichia coli lysine and diaminopimelate biosynthesis pathway 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.8 Escherichia coli P04036
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ mechanism Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H
-
 Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H lysine and diaminopimelate biosynthesis pathway Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.1.8 More homotetramer with identical subunits, each subunit with 2 domains, structure analysis Escherichia coli
1.17.1.8 tetramer
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.8 NADH
-
 Escherichia coli
1.17.1.8 NADPH
-
 Escherichia coli