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Literature summary extracted from

  • Reddy, S.G.; Scapin, G.; Blanchard, J.S.
    Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: Thermodynamic and structural analysis of binary complexes (1996), Biochemistry, 35, 13294-13302.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.17.1.8 hanging drop vapour diffusion method, crystal structure x-ray analysis and binding study with NADPH, NADH, 3-acetyl-NADH, and reduced nicotinamide hypoxanthine dinucleotide phosphate and other pyridine nucleotide derivatives in complex with the enzyme Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H Escherichia coli
-
 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.8 Escherichia coli P04036
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.17.1.8 (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ structure of substrate-cofactor-complex Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.8 2,3-dihydrodipicolinate + NAD(P)H
-
 Escherichia coli 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.1.8 DHPR
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.8 additional information broad pyridine nucleotide specificity, binding study with NADPH, NADH, 3-acetyl-NADH, and nicotinamide hypoxanthine dinucleotide phosphate reduced and other pyridine nucleotide derivatives Escherichia coli
1.17.1.8 NADH thermodynamic binding parameters Escherichia coli
1.17.1.8 NADH twice as effective as NADPH Escherichia coli
1.17.1.8 NADPH thermodynamic binding parameters Escherichia coli