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Literature summary extracted from

  • Fazel, A.M.; Jensen, R.A.
    Obligatory biosynthesis of L-tyrosine via the pretyrosine branchlet in coryneform bacteria (1979), J. Bacteriol., 138, 805-815.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.78 additional information mutant pheA5 and double-mutant pheA5 shkA1 by mutagenesis and growth selection, reduced activity [Brevibacterium] flavum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.78 L-tyrosine no inhibition [Brevibacterium] flavum
1.3.1.78 L-tyrosine no inhibition Corynebacterium ammoniagenes
1.3.1.78 L-tyrosine no inhibition Corynebacterium glutamicum
1.3.1.78 p-hydroxymercuribenzoate
-
 [Brevibacterium] flavum
1.3.1.78 p-hydroxymercuribenzoate
-
 Corynebacterium ammoniagenes
1.3.1.78 p-hydroxymercuribenzoate
-
 Corynebacterium glutamicum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.78 additional information
-
 additional information
-
 [Brevibacterium] flavum
1.3.1.78 additional information
-
 additional information
-
 Corynebacterium glutamicum
1.3.1.78 additional information
-
 additional information
-
 Corynebacterium ammoniagenes

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.78 68000
-
 gel filtration Corynebacterium ammoniagenes
1.3.1.78 158000
-
 gel filtration [Brevibacterium] flavum
1.3.1.78 158000
-
 gel filtration Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.78 L-arogenate + NAD+ [Brevibacterium] flavum
-
 L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ Corynebacterium glutamicum
-
 L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+ Corynebacterium ammoniagenes
-
 L-tyrosine + NADH + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.12 no activity in coryneform bacteria
-
-
-
1.3.1.78 Corynebacterium ammoniagenes
-
-
-
1.3.1.78 Corynebacterium glutamicum
-
-
-
1.3.1.78 [Brevibacterium] flavum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.78 partial [Brevibacterium] flavum
1.3.1.78 partial Corynebacterium glutamicum
1.3.1.78 partial Corynebacterium ammoniagenes

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.78 additional information
-
-
 [Brevibacterium] flavum
1.3.1.78 additional information
-
-
 Corynebacterium glutamicum
1.3.1.78 additional information
-
-
 Corynebacterium ammoniagenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.78 L-arogenate + NAD(P)+
-
 [Brevibacterium] flavum L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD(P)+
-
 Corynebacterium glutamicum L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD(P)+
-
 Corynebacterium ammoniagenes L-tyrosine + NAD(P)H + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 [Brevibacterium] flavum L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 Corynebacterium glutamicum L-tyrosine + NADH + CO2
-
 ?
1.3.1.78 L-arogenate + NAD+
-
 Corynebacterium ammoniagenes L-tyrosine + NADH + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.78 33
-
-
 [Brevibacterium] flavum
1.3.1.78 33
-
-
 Corynebacterium glutamicum
1.3.1.78 33
-
-
 Corynebacterium ammoniagenes

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.78 7.8
-
-
 [Brevibacterium] flavum
1.3.1.78 7.8
-
-
 Corynebacterium glutamicum
1.3.1.78 7.8
-
-
 Corynebacterium ammoniagenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.78 NAD+
-
 [Brevibacterium] flavum
1.3.1.78 NAD+
-
 Corynebacterium glutamicum
1.3.1.78 NAD+
-
 Corynebacterium ammoniagenes
1.3.1.78 NADP+
-
 [Brevibacterium] flavum
1.3.1.78 NADP+
-
 Corynebacterium glutamicum
1.3.1.78 NADP+
-
 Corynebacterium ammoniagenes