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Literature summary extracted from

  • Schubel, U.; Kraut, M.; Morsdorf, G.; Meyer, O.
    Molecular characterization of the gene cluster coxMSL encoding the molybdenum-containing carbon monoxide dehydrogenase of Oligotropha carboxidovorans (1995), J. Bacteriol., 177, 2197-2203.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.5.3 large, medium, and small subunits of CODH are encoded by the structural genes coxL, coxM, and coxS, respectively. They reside on a 128-kb megaplasmid pHCG3, DNA and amino acid sequence determination and analysis, and molecular organization of the coxMSL gene cluster, sequence comparisons Afipia carboxidovorans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.5.3 Molybdenum
-
 Afipia carboxidovorans
1.2.5.3 [2Fe-2S] cluster two distinct [2Fe-2S] clusters, the small subunit CoxS contains motifs indicative of type I and II [2Fe-2S] cluster, structure and binding strutcures, overview Afipia carboxidovorans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.7.4 273500
-
 deduced from amino acid sequence Afipia carboxidovorans

Organism

EC Number Organism UniProt Comment Textmining
1.2.5.3 Afipia carboxidovorans P19919 and P19920 and P19921 large, medium, and small subunits; large, medium, and small subunits of CODH are encoded by the structural genes coxL, coxM, and coxS, respectively. They reside on the 128-kb megaplasmid pHCG3
-
1.2.5.3 Afipia carboxidovorans OM5 P19919 and P19920 and P19921 large, medium, and small subunits; large, medium, and small subunits of CODH are encoded by the structural genes coxL, coxM, and coxS, respectively. They reside on the 128-kb megaplasmid pHCG3
-
1.2.7.4 Afipia carboxidovorans
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.2.5.3 CODH
-
 Afipia carboxidovorans
1.2.5.3 molybdenum-containing carbon monoxide dehydrogenase
-
 Afipia carboxidovorans

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.5.3 FAD the GLGTYG sequence, residues 564 to 569, in large subunit CoxL is identical to dinucleotide-binding motif GXGXXG/A, an FAD binding site. The FAD-binding domain of the ferredoxin-NADP+ reductase type is absent Afipia carboxidovorans
1.2.5.3 molybdenum cofactor
-
 Afipia carboxidovorans
1.2.7.4 flavin adenine dinucleotide suggested from gene sequence analysis Afipia carboxidovorans
1.2.7.4 molybdopterin cytosine dinucleotide suggested from gene sequence analysis Afipia carboxidovorans

General Information

EC Number General Information Comment Organism
1.2.5.3 physiological function the enzyme is a molybdenum-containing iron-sulfur flavoprotein and is the key enzyme in the chemolithoautotrophic utilization of CO by Oligotropha carboxidovorans strain OM5. Conserved protein building blocks constitute CODH and the other molybdenum hydroxylases Afipia carboxidovorans