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Literature summary extracted from

  • Raybuck, S.A.; Bastian, N.R.; Orme-Johnson, W.H.; Walsh, C.T.
    Kinetic characterization of the carbon monoxide-acetyl-CoA (carbonyl group) exchange activity of the acetyl-CoA synthesizing CO dehydrogenase from Clostridium thermoaceticum (1988), Biochemistry, 27, 7698-7702.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.7.4 butyryl-CoA
-
Moorella thermoacetica
1.2.7.4 CoASH
-
Moorella thermoacetica
1.2.7.4 crotonyl-CoA
-
Moorella thermoacetica
1.2.7.4 dephospho-CoASH
-
Moorella thermoacetica
1.2.7.4 desulfo-CoA
-
Moorella thermoacetica
1.2.7.4 pivaloylpantetheine-SH
-
Moorella thermoacetica
1.2.7.4 propionyl-CoA
-
Moorella thermoacetica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.7.4 0.01
-
CO CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 0.6
-
acetyl-CoA CO/acetyl-CoA exchange reaction Moorella thermoacetica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.4 CO + H2O + electron acceptor Moorella thermoacetica catalyzes the final step in the synthesis of acetyl-CoA ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.4 Moorella thermoacetica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.4 CO + H2O + electron acceptor catalyzes the final step in the synthesis of acetyl-CoA Moorella thermoacetica ?
-
?
1.2.7.4 CO + H2O + methyl viologen catalyzes the synthesis of acetyl-CoA from methyl corrinoid, Co and CoASH Moorella thermoacetica CO2 + reduced methyl viologen
-
?
1.2.7.4 CO + H2O + methyl viologen catalyzes an exchange reaction between CO and the carbonyl group of acetyl-CoA Moorella thermoacetica CO2 + reduced methyl viologen
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.7.4 1.17
-
CO
-
Moorella thermoacetica
1.2.7.4 7.33
-
CO acetyl-CoA/CO exchange reaction Moorella thermoacetica

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.7.4 0.007
-
CoASH inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 0.035
-
dephospho-CoASH inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 1.2
-
pivaloylpantetheine-SH inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 1.3
-
propionyl-CoA inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 1.4
-
crotonyl-CoA inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 1.45
-
butyryl-CoA inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica
1.2.7.4 6
-
desulfo-CoA inhibition of CO/acetyl-CoA exchange reaction Moorella thermoacetica