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Literature summary extracted from

  • Seravalli, J.; Kumar, M.; Lu, W.P.; Ragsdale, S.W.
    Mechanism of CO oxidation by carbon monoxide dehydrogenase from Clostridium thermoaceticum and its inhibition by anions (1995), Biochemistry, 34, 7879-7888.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.7.4 SCN- binds to C-center, mixed partial inhibition Moorella thermoacetica

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.4 Moorella thermoacetica
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.7.4 CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+ ping-pong mechanism Moorella thermoacetica
a

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.7.4 600
-
 CO CO oxidation, at 55°C, pH 7.6 Moorella thermoacetica
1.2.7.4 3250
-
 CO CO oxidation, extrapolated maximum value at 55°C, pH 10.8 Moorella thermoacetica

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.7.4 16
-
 SCN assay at pH 5.5, Ki depends on pH and temperature Moorella thermoacetica
1.2.7.4 830
-
 SCN assay at pH 10.7, Ki depends on pH and temperature Moorella thermoacetica