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Literature summary extracted from

  • Dragolovich, J.; Pierce, S.K.
    Characterization of partially purified betaine aldehyde dehydrogenase from horseshoe crab (Limulus polyphemus) cardiac mitochondria (1994), J. Exp. Zool., 270, 417-425.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.8 Ca2+ above 0.00075 mM Limulus polyphemus
1.2.1.8 glycine betaine
-
Limulus polyphemus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.8 0.133
-
Betaine aldehyde
-
Limulus polyphemus
1.2.1.8 0.267
-
NADP+
-
Limulus polyphemus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.8 mitochondrion
-
Limulus polyphemus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.8 Ca2+ increase of concentration from 0 to 0.00075 mM produces a 2fold increase in activity Limulus polyphemus
1.2.1.8 K+ stimulates Limulus polyphemus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD+ + H2O Limulus polyphemus
-
betaine + NADH
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Limulus polyphemus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.8 heart
-
Limulus polyphemus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.8 213
-
-
Limulus polyphemus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.8 betaine aldehyde + NAD+ + H2O
-
Limulus polyphemus betaine + NADH
-
?
1.2.1.8 betaine aldehyde + NADP+ + H2O
-
Limulus polyphemus betaine + NADPH
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.8 25
-
-
Limulus polyphemus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.2.1.8 20 40 20°C: about 45% of maximal activity, 40°C: about 70% of maximal activity Limulus polyphemus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.8 7.5
-
-
Limulus polyphemus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.8 7 8 pH 7.0: about 35% of maximal activity, pH 8.0: about 70% of maximal activity Limulus polyphemus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.8 NAD+ NAD+ is preferred over NADP+ Limulus polyphemus
1.2.1.8 NADP+ NAD+ is preferred over NADP+ Limulus polyphemus