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Literature summary extracted from
- Evidence for mitochondrial localization of betaine aldehyde dehydrogenase in rat liver: purification, characterization, and comparison with human cytoplasmic E3 isozyme (1999), Biochem. Cell Biol., 77, 179-187.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.8 | cimetidine | - |
Homo sapiens |  |
| 1.2.1.8 | cimetidine | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.8 | 0.004 | - |
4-Aminobutyraldehyde | mitochondrial enzyme | Rattus norvegicus | |
| 1.2.1.8 | 0.005 | - |
4-Aminobutyraldehyde | - |
Homo sapiens | |
| 1.2.1.8 | 0.014 | - |
acetaldehyde | - |
Rattus norvegicus | |
| 1.2.1.8 | 0.034 | - |
NAD+ | mitochondrial enzyme | Rattus norvegicus | |
| 1.2.1.8 | 0.035 | - |
NAD+ | - |
Homo sapiens | |
| 1.2.1.8 | 0.05 | - |
acetaldehyde | - |
Homo sapiens | |
| 1.2.1.8 | 0.118 | - |
Betaine aldehyde | mitochondrial enzyme | Rattus norvegicus | |
| 1.2.1.8 | 0.153 | - |
glycolaldehyde | - |
Rattus norvegicus | |
| 1.2.1.8 | 0.24 | - |
glycolaldehyde | - |
Homo sapiens | |
| 1.2.1.8 | 0.26 | - |
Betaine aldehyde | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.2.1.8 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
| 1.2.1.8 | cytoplasm | NAD+-linked aldehyde dehydrogenase E3 isoenzyme | Homo sapiens | 5737 | - |
| 1.2.1.8 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.8 | 53000 | - |
x * 53000 + x * 59000, SDS-PAGE | Rattus norvegicus |
| 1.2.1.8 | 54000 | - |
x * 54000, SDS-PAGE | Homo sapiens |
| 1.2.1.8 | 59000 | - |
x * 53000 + x * 59000, SDS-PAGE | Rattus norvegicus |
| 1.2.1.8 | 230000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O | Rattus norvegicus | the enzyme has an important function in the metabolism of choline to betaine, a major osmolyte. Betaine is also important in mammalian organisms as a major methyl group donor and nitrogen source | betaine + NADH | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.8 | Homo sapiens | - |
aldehyde dehydrogenase E3 isoenzyme is a betaine aldehyde dehydrogenase | - |
| 1.2.1.8 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.1.8 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.1.8 | liver | - |
Homo sapiens | - |
| 1.2.1.8 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.8 | 3.3 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.8 | 4-aminobutyraldehyde + NAD+ + H2O | - |
Homo sapiens | 4-aminobutyrate + NADH | - |
? | |
| 1.2.1.8 | 4-aminobutyraldehyde + NAD+ + H2O | - |
Rattus norvegicus | 4-aminobutyrate + NADH | - |
? | |
| 1.2.1.8 | acetaldehyde + NAD+ + H2O | - |
Homo sapiens | acetate + NADH + H+ | - |
? | |
| 1.2.1.8 | acetaldehyde + NAD+ + H2O | - |
Rattus norvegicus | acetate + NADH + H+ | - |
? | |
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O | - |
Homo sapiens | betaine + NADH | - |
? | |
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O | - |
Rattus norvegicus | betaine + NADH | - |
? | |
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O | the enzyme has an important function in the metabolism of choline to betaine, a major osmolyte. Betaine is also important in mammalian organisms as a major methyl group donor and nitrogen source | Rattus norvegicus | betaine + NADH | - |
? | |
| 1.2.1.8 | glycolaldehyde + NAD+ + H2O | - |
Homo sapiens | glycolate + NADH | - |
? | |
| 1.2.1.8 | glycolaldehyde + NAD+ + H2O | - |
Rattus norvegicus | glycolate + NADH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.2.1.8 | ? | x * 54000, SDS-PAGE | Homo sapiens |
| 1.2.1.8 | ? | x * 53000 + x * 59000, SDS-PAGE | Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.8 | 0.001 | - |
cimetidine | - |
Homo sapiens | |
| 1.2.1.8 | 0.033 | - |
cimetidine | - |
Rattus norvegicus | |
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