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Literature summary extracted from
- Betaine-aldehyde dehydrogenase from leaves of Amaranthus hypochondriacus L. exhibits an Iso Ordered Bi Bi steady state mechanism (1993), J. Biol. Chem., 268, 23818-23823.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.8 | AMP | competitive with respect to NAD+ and mixed with betaine aldehyde and uncompetitive with respect to NAD+ | Amaranthus hypochondriacus |  |
| 1.2.1.8 | choline | - |
Amaranthus hypochondriacus | |
| 1.2.1.8 | glycine betaine | no inhibition up to 10 mM | Amaranthus hypochondriacus | |
| 1.2.1.8 | NADH | mixed inhibitor against NAD+ and betaine aldehyde | Amaranthus hypochondriacus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.8 | 0.0395 | - |
NAD+ | - |
Amaranthus hypochondriacus | |
| 1.2.1.8 | 0.0561 | - |
Betaine aldehyde | - |
Amaranthus hypochondriacus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.8 | Amaranthus hypochondriacus | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ | iso-ordered bi-bi steady state mechanism | Amaranthus hypochondriacus | |
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O = betaine + NADH + 2 H+ | NAD+ is the first substrate to bind to the enzyme and NADH is the last product to dissociate from it | Amaranthus hypochondriacus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.2.1.8 | leaf | - |
Amaranthus hypochondriacus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.8 | betaine aldehyde + NAD+ + H2O | - |
Amaranthus hypochondriacus | betaine + NADH | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.8 | 0.896 | - |
AMP | with respect to NAD+ | Amaranthus hypochondriacus | |
| 1.2.1.8 | 4.1 | - |
choline | with respect to betaine aldehyde | Amaranthus hypochondriacus | |
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Release 2023.1 (January 2023)
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