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Literature summary extracted from

  • Guzman-Partida, A.M.; Valenzuela-Soto, E.M.
    Porcine kidney betaine aldehyde dehydrogenase: purification and properties (1998), Comp. Biochem. Physiol. B, 119, 485-491.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.8 NH4+ slight activation up to about 0.3 M Sus scrofa
1.2.1.8 Pro 0.1 M, 35% activation, at high substrate concentrations Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.8 glycine betaine
-
 Sus scrofa
1.2.1.8 K+ 1.0 mM, 35% inhibition Sus scrofa
1.2.1.8 Mg2+ 0.4 M, complete inhibition Sus scrofa
1.2.1.8 NaCl 40% inhibition above 0.3 M Sus scrofa
1.2.1.8 NH4+ above 0.4 M, more than 60% inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.8 0.04
-
 NAD+
-
 Sus scrofa
1.2.1.8 0.127
-
 Betaine aldehyde
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.8 Mg2+ 0.2 M, slight activation Sus scrofa
1.2.1.8 Na+ slight activation up to about 0.3 M Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.8 52000
-
 x * 52000, SDS-PAGE Sus scrofa
1.2.1.8 688000
-
 non-denaturing PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.8 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.8
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.8 kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.8 additional information
-
-
 Sus scrofa

Storage Stability

EC Number Storage Stability Organism
1.2.1.8 -70°C, stable for several months Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.8 acetaldehyde + NAD+ + H2O at 20% of the activity with betaine aldehyde Sus scrofa acetate + NADH + H+
-
 ?
1.2.1.8 betaine aldehyde + NAD+ + H2O
-
 Sus scrofa betaine + NADH
-
 ir
1.2.1.8 butyraldehyde + NAD+ + H2O at 40% of the activity with betaine aldehyde Sus scrofa butyrate + NADH
-
 ?
1.2.1.8 glyceraldehyde + NAD+ + H2O at 30% of the activity with betaine aldehyde Sus scrofa glycerate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.8 ? x * 52000, SDS-PAGE Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.8 9.5
-
-
 Sus scrofa

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.2.1.8 5.5 9.5 stable Sus scrofa