Literature summary extracted from

Gamper, H.; Moses, V.
Enzyme organization in the proline biosynthetic pathway of Escherichia coli (1974), Biochim. Biophys. Acta, 354, 75-87.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.2.1.41	L-5-glutamyl phosphate + NADPH	Escherichia coli	gamma-glutamyl kinase (the first enzyme of proline biosynthetic pathway) and gamma-glutamyl phosphate reductase (second enzyme) form a complex which stabilizes the labile intermediate i.e. gamma-glutamyl phosphate	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.1.41	Escherichia coli	-	various strains	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.2.1.41	L-5-glutamyl phosphate + NADPH	gamma-glutamyl kinase (the first enzyme of proline biosynthetic pathway) and gamma-glutamyl phosphate reductase (second enzyme) form a complex which stabilizes the labile intermediate i.e. gamma-glutamyl phosphate	Escherichia coli	?	-	?
1.2.1.41	L-glutamate 5-semialdehyde + phosphate + NADP+	-	Escherichia coli	L-5-glutamyl phosphate + NADPH	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.2.1.41	NADPH	-	Escherichia coli

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Release 2023.1 (January 2023)