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Literature summary extracted from

  • Kramer, J.J.; Gooding, R.C.; Jones, M.E.
    A radiochemical assay for a NADP+-specific gamma-glutamate semialdehyde dehydrogenase extracted from mitochondrial membrane of rat intestinal epithelial cells (1988), Anal. Biochem., 168, 380-386.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.41 phosphate 100 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.41 0.19
-
 NADP+
-
 Rattus norvegicus
1.2.1.41 1.8
-
 L-glutamate 5-semialdehyde
-
 Rattus norvegicus
1.2.1.41 11.3
-
 phosphate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.41 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.41 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.41 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.41 epithelium of the intestine Rattus norvegicus
-
1.2.1.41 intestine epithelium Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.41 L-glutamate 5-semialdehyde + phosphate + NADP+ L-glutamate 5-semialdehyde spontaneously cyclizes to delta-1-pyrroline-5-carboxylic acid Rattus norvegicus L-5-glutamyl phosphate + NADPH
-
 ?
1.2.1.41 L-glutamate 5-semialdehyde + phosphate + NADP+ L-glutamate 5-semialdehyde spontaneously cyclizes to pyrroline 5-carboxylate. The product gamma-glutamyl phosphate decomposes to pyrrolidone 5-carboxylate. Rattus norvegicus gamma-glutamyl phosphate + NADPH + H+
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.41 37
-
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.41 7
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.41 NADPH
-
 Rattus norvegicus