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Literature summary extracted from

  • Hanlon, S.P.; Hill, T.K.; Flavell, M.A.; Stringfellow, J.M.; Cooper, R.A.
    2-Phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression (1997), Microbiology, 143, 513-518.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.39 3,4-dihydroxyphenylacetaldehyde above 0.01 mM Escherichia coli
1.2.1.39 4-hydroxyphenylacetaldehyde above 0.01 mM Escherichia coli
1.2.1.39 phenylacetaldehyde above 0.01 mM Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.39 0.004
-
 4-hydroxyphenylacetaldehyde
-
 Escherichia coli
1.2.1.39 0.006
-
 3,4-dihydroxyphenylacetaldehyde
-
 Escherichia coli
1.2.1.39 0.007
-
 phenylacetaldehyde
-
 Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.39 54000
-
 x * 54000, SDS-PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.39 phenylacetaldehyde + NAD+ + H2O Escherichia coli a positive regulatory protein required for expression of phenylacetaldehyde dehydrogenase is located next to the PAD gene ?
-
 ?
1.2.1.39 phenylacetaldehyde + NAD+ + H2O Escherichia coli enzyme is involved in the catabolism of 2-phenylethylamine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.39 Escherichia coli
-
 K12
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.39
-
 Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.39 41
-
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.39 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
-
 Escherichia coli 3,4-dihydroxyphenylacetate + NADH + H+
-
 ?
1.2.1.39 4-hydroxyphenylacetaldehyde + NAD+ + H2O
-
 Escherichia coli 4-hydroxyphenylacetate + NADH + H+
-
 ?
1.2.1.39 phenylacetaldehyde + NAD+ + H2O
-
 Escherichia coli phenylacetate + NADH + H+
-
 ?
1.2.1.39 phenylacetaldehyde + NAD+ + H2O a positive regulatory protein required for expression of phenylacetaldehyde dehydrogenase is located next to the PAD gene Escherichia coli ?
-
 ?
1.2.1.39 phenylacetaldehyde + NAD+ + H2O enzyme is involved in the catabolism of 2-phenylethylamine Escherichia coli ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.39 ? x * 54000, SDS-PAGE Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.39 NAD+
-
 Escherichia coli