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Literature summary extracted from

  • Posch, K.C.; Burns, R.D; Napoli, J.L.
    Biosynthesis of all-trans-retinoic acid from retinal. Recognition of retinal bound to cellular retinol binding protein (type I) as substrate by a purified cytosolic dehydrogenase (1992), J. Biol. Chem., 267, 19676-19682.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.36 CRBP facilitates conversion of retinal into retinoic acid Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.36 retinal substrate inhibition with concentration greater than 0.006 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.36 0.76
-
 retinal
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.36 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.36 55000
-
 4 * 55000, SDS-PAGE Rattus norvegicus
1.2.1.36 214000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.36
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.36 0.265
-
-
 Rattus norvegicus

Subunits

EC Number Subunits Comment Organism
1.2.1.36 homotetramer 4 * 55000, SDS-PAGE Rattus norvegicus