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Literature summary extracted from

  • Namba, Y.; Yoshizawa, K.; Ejima, A.; Hayashi, T.; Kaneda, T.
    Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis (1969), J. Biol. Chem., 244, 4437-4447.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.25 2-oxoisopentanoate competitive Bacillus subtilis
1.2.1.25 iodoacetate
-
Bacillus subtilis
1.2.1.25 L-2-Oxo-3-methylpentanoate competitive Bacillus subtilis
1.2.1.25 NEM
-
Bacillus subtilis
1.2.1.25 PCMB
-
Bacillus subtilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.25 0.11
-
CoA
-
Bacillus subtilis
1.2.1.25 1.66
-
L-alpha-keto-beta-methylvalerate
-
Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.25 Bacillus subtilis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.25
-
Bacillus subtilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.25 3-methyl-2-oxobutanoate + CoA + NAD+ specific for the L-isomer Bacillus subtilis 2-methylpropanoyl-CoA + CO2 + NADH
-
?
1.2.1.25 4-methyl-2-oxopentanoate + CoA + NAD+
-
Bacillus subtilis 3-methyl-butanoyl-CoA + CO2 + NADH
-
?
1.2.1.25 L-alpha-keto-beta-methylvalerate + CoA + NAD+
-
Bacillus subtilis ?
-
r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.25 7
-
-
Bacillus subtilis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.2.1.25 6 7.5 pH 6.0: about 25% of maximal activity, pH 7.5: about 45% of maximal activity Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.25 CoA required Bacillus subtilis
1.2.1.25 additional information CoA and NAD+ can be replaced by potassium ferricyanide but the activity is much lower Bacillus subtilis
1.2.1.25 additional information enzyme probably identical with EC 1.2.4.4 Bacillus subtilis
1.2.1.25 NAD+ required Bacillus subtilis