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Literature summary extracted from

  • Hegeman, G.D.; Cohen, G.N.; Morgan, R.
    Aspartic semialdehyde dehydrogenase (Escherichia coli K12) (1970), Methods Enzymol., 17A, 708-713.
No PubMed abstract available

General Stability

EC Number General Stability Organism
1.2.1.11 lyophilization of purified or partially purified enzyme, slight loss of activity Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 aromatic aldehydes e.g.: benzaldehyde, weak Escherichia coli
1.2.1.11 Borate
-
Escherichia coli
1.2.1.11 formaldehyde
-
Escherichia coli
1.2.1.11 Glutaraldehyde
-
Escherichia coli
1.2.1.11 iodoacetate
-
Escherichia coli
1.2.1.11 K+
-
Escherichia coli
1.2.1.11 additional information not: chelating agents Escherichia coli
1.2.1.11 N-ethylmaleimide
-
Escherichia coli
1.2.1.11 Na+
-
Escherichia coli
1.2.1.11 NH4+
-
Escherichia coli
1.2.1.11 p-hydroxymercuribenzoate
-
Escherichia coli
1.2.1.11 Tris salts
-
Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.11 0.09
-
NADP+
-
Escherichia coli
1.2.1.11 0.2
-
L-aspartate 4-semialdehyde
-
Escherichia coli
1.2.1.11 6
-
HAsO42-
-
Escherichia coli
1.2.1.11 9
-
phosphate
-
Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.11 70000
-
gel filtration Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Escherichia coli
-
K-12
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.11 K-12, using ammonium sulfate precipitation and column chromatography on Sephadex G-200 and DEAE-Sephadex A-50 Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.11 120
-
-
Escherichia coli

Storage Stability

EC Number Storage Stability Organism
1.2.1.11 frozen or on ice, after dialysis, 1 month stable Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + HasO42- + NADP+
-
Escherichia coli ?
-
r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
Escherichia coli L-4-aspartyl phosphate + NADPH
-
?
1.2.1.11 additional information maximum velocity with HAsO42- is 0.4 times that with HPO42- Escherichia coli ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.11 25
-
assay at Escherichia coli

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.11 50
-
20 min, crude extract, 20% loss of activity Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.11 9
-
-
Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 additional information NAD+: 0.1% or less the rate of reaction with NADP+ Escherichia coli
1.2.1.11 NADP+
-
Escherichia coli