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Literature summary extracted from

  • Bicikova, M.; Hampl, R.; Hill, M.; Starka, L.
    Inhibition of steroid 17alpha-hydroxylase and C17,20-lyase in the human testis by epitestosterone (1993), J. Steroid Biochem. Mol. Biol., 46, 515-518.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 17alpha-Hydroxy-4-androsten-3-one competitive inhibitor of 17alpha-hydroxylation of pregnenolone and of the subsequent C17,20-side chain cleavage reaction Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.19 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + A + H2O product eliminates at C20,21 acetate to yield dehydroepiandrosterone ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + A + H2O product eliminates at C20,21 acetate to yield dehydroepiandrosterone ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.14.19 0.00124
-
 17alpha-hydroxyandrosten-3-one C17,20-lyase activity Homo sapiens
1.14.14.19 0.0096
-
 17alpha-hydroxyandrosten-3-one 17alpha-hydroxylase activity Homo sapiens