Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fournet, N.; Weitsman, S.R.; Zachow, R.J.; Magoffin, D.A.
    Transforming growth factor-beta inhibits ovarian 17alpha-hydroxylase activity by a direct noncompetitive mechanism (1996), Endocrinology, 137, 166-174.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 transforming growth factor-beta1 inhibits 17alpha-hydroxylation in vitro by a noncompetitive mechanism Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 ovary theca-interstitial cell Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.19 NADPH
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.14.19 0.0000000464
-
 transforming growth factor-beta1
-
 Rattus norvegicus