EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.14.19 | medicine | inhibition of steroid 17alpha-monooxygenase is an important therapeutic strategy in order to inhibit tumor growth in prostate cancer | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.19 | expression in Escherichia coli XL1 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | 20-hydroxyiminopregna-4,14,16-trien-3-one | at 0.0002 mM 50% inhibition | Homo sapiens | |
1.14.14.19 | 20-hydroxyiminopregna-4,16-dien-3-one | at 0.0001 mM 50% inhibition | Homo sapiens | |
1.14.14.19 | 20-hydroxyiminopregna-5,14,16-trien-3beta-ol | at 0.0002 mM 50% inhibition | Homo sapiens | |
1.14.14.19 | 20-hydroxyiminopregna-5,16-dien-3beta-ol | at 0.00017 mM 50% inhibition | Homo sapiens | |
1.14.14.19 | 21-hydroxyimino-21-methylpregn-4-en-3-one | at 0.0036 mM 50% inhibition | Rattus norvegicus | |
1.14.14.19 | 21-hydroxyiminopregn-4-en-3-one | at 0.0003 mM 50% inhibition, also 5alpha-reductase inhibitor | Homo sapiens | |
1.14.14.19 | 21-hydroxyiminopregn-4-en-3-one | at 0.0003 mM 50% inhibition, also 5alpha-reductase inhibitor | Rattus norvegicus | |
1.14.14.19 | 21-hydroxyiminopregn-5-en-3beta-ol | at 0.00027 mM 50% inhibition | Homo sapiens | |
1.14.14.19 | 21-hydroxyiminopregn-5-en-3beta-ol | at 0.00276 mM 50% inhibition | Rattus norvegicus | |
1.14.14.19 | 21-hydroxyiminopregna-4,17(20)-dien-3-one | at 0.00018 mM 50% inhibition, also 5alpha-reductase inhibitor | Homo sapiens | |
1.14.14.19 | 21-hydroxyiminopregna-4,17(20)-dien-3-one | at 0.00014 mM 50% inhibition | Rattus norvegicus | |
1.14.14.19 | 21-hydroxyiminopregna-5,17(29)-dien-3beta-ol | at 0.000077 mM 50% inhibition | Homo sapiens | |
1.14.14.19 | 21-hydroxyiminopregna-5,17(29)-dien-3beta-ol | at 0.00052 mM 50% inhibition | Rattus norvegicus | |
1.14.14.19 | 21-methylpregn-5-en-3beta-ol-21-one | at 0.0098 mM 50% inhibition | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.19 | microsome | - |
Homo sapiens | - |
- |
1.14.14.19 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.19 | Homo sapiens | - |
- |
- |
1.14.14.19 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.19 | testis | - |
Homo sapiens | - |
1.14.14.19 | testis | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.19 | CYP 17 | - |
Homo sapiens |
1.14.14.19 | P450 17 | - |
Homo sapiens |
1.14.14.19 | P450 17 | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | NADPH | - |
Homo sapiens | |
1.14.14.19 | NADPH | - |
Rattus norvegicus |