EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | 3beta-hydroxy-23,24-bisnor-5-cholenic-hydroxamic acid | at 0.0025 mM 20% inhibition | Homo sapiens | |
1.14.14.19 | 3beta-hydroxy-23,24-bisnor-5-cholenic-hydroxamic acid | at 0.125 mM 19% inhibition | Rattus norvegicus | |
1.14.14.19 | 3beta-hydroxy-5-androsten-17beta-hydroxamic acid | at 0.0025 mM 17% inhibition | Homo sapiens | |
1.14.14.19 | 3beta-hydroxy-5-androsten-17beta-hydroxamic acid | at 0.125 mM 18% inhibition | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.19 | microsome | - |
Homo sapiens | - |
- |
1.14.14.19 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.19 | Homo sapiens | - |
- |
- |
1.14.14.19 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.19 | testis | - |
Homo sapiens | - |
1.14.14.19 | testis | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
1.14.14.19 | progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.19 | P450 17 | - |
Homo sapiens |
1.14.14.19 | P450 17 | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.14.19 | 32 | - |
- |
Rattus norvegicus |
1.14.14.19 | 37 | - |
- |
Homo sapiens |
1.14.14.19 | 37 | - |
- |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.19 | NADPH | - |
Homo sapiens | |
1.14.14.19 | NADPH | - |
Rattus norvegicus |