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Literature summary extracted from

  • Soberman, R.J.; Okita, R.T.; Fitzsimmons, B.; Rokach, J.; Spur, B.; Austen, K.F.
    Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase (1987), J. Biol. Chem., 262, 12421-12427.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.94 leukotriene B5
-
 Homo sapiens
1.14.14.94 additional information overview: inhibition by alternative substrates Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.94 0.002
-
 leukotriene B4
-
 Homo sapiens
1.14.14.94 0.0038
-
 6-trans-12-epi-Leukotriene B4
-
 Homo sapiens
1.14.14.94 0.0056
-
 5-Deoxy-leukotriene B4
-
 Homo sapiens
1.14.14.94 0.0066
-
 5-epi-Leukotriene B4
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.94 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.94 (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens inactivation of leukotriene B4, a mediator of inflammation (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.94 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.94 leukocyte polymorphonuclear Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.94 (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 inactivation of leukotriene B4, a mediator of inflammation Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 5-deoxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5-deoxy-20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 5-epi-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 5-epi-20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 6-trans-12-epi-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 6-trans-12-epi-20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 leukotriene B4 is identical with (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.94 additional information overview, stereochemical requirement for substrate specificity Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.14.94 0.001
-
 leukotriene B5
-
 Homo sapiens