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Literature summary extracted from

  • Jansen, G.A.; Wanders, R.J.A.
    L-2-Hydroxyglutarate dehydrogenase: identification of a novel enzyme activity in rat and human liver. Implications for L-2-hydroxyglutaric acidemia (1993), Biochim. Biophys. Acta, 1225, 53-56.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.99.2 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.99.2 Homo sapiens
-
-
-
1.1.99.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.99.2 liver
-
 Homo sapiens
-
1.1.99.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.99.2 (S)-2-hydroxyglutarate + NAD+
-
 Homo sapiens 2-oxoglutarate + NADH + H+
-
 ?
1.1.99.2 (S)-2-hydroxyglutarate + NAD+
-
 Rattus norvegicus 2-oxoglutarate + NADH + H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.99.2 7.3 9.3 active over a wide pH range, without a clear optimum Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.99.2 7.3 9.3 active over a wide pH range, without a clear optimum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.99.2 NAD+
-
 Homo sapiens
1.1.99.2 NAD+
-
 Rattus norvegicus