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Literature summary extracted from

  • Moreau, R.A.; Huang, A.H.C.
    Oxidation of fatty alcohol in the cotyledons of jojoba seedlings (1979), Arch. Biochem. Biophys., 194, 422-430.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.48 dithiothreitol 5 mM causes 58% increase in activity Simmondsia chinensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.3.20 additional information no inhibitor: cyanide Simmondsia chinensis
1.1.3.20 p-chloromercuribenzoate 70% loss of activity at 0.1 mM, completely reversible with dithiothreitol Simmondsia chinensis
1.2.1.48 Cu2+ 1 mM causes 60% inhibition Simmondsia chinensis
1.2.1.48 p-chloromercuribenzoate 0.1 mM causes complete inhibition Simmondsia chinensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.48 0.004
-
 decyl aldehyde
-
 Simmondsia chinensis
1.2.1.48 0.25
-
 NAD+
-
 Simmondsia chinensis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.3.20 glyoxysome
-
 Simmondsia chinensis 9514
-
1.1.3.20 membrane
-
 Simmondsia chinensis 16020
-
1.1.3.20 oil body
-
 Simmondsia chinensis
-
-
1.2.1.48 membrane localized primarily in the membrane of wax bodies Simmondsia chinensis 16020
-
1.2.1.48 membrane also present in other cellular membranes Simmondsia chinensis 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.48 Mn2+ 1 mM causes 24% increase in activity Simmondsia chinensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.20 long-chain alcohol + O2 Simmondsia chinensis reaction in wax ester catabolism in the storage wax bodies of jojoba plant during germination ?
-
 ?
1.1.3.20 long-chain alcohol + O2 Simmondsia chinensis monounsaturated long-chain alcohols ?
-
 ?
1.2.1.48 long-chain aldehyde + NAD+ Simmondsia chinensis mobilization of intracellular wax esters in the cotyledon during germination ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.20 Simmondsia chinensis
-
 jojoba
-
1.2.1.48 Simmondsia chinensis
-
 jojoba
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.3.20 a long-chain alcohol + O2 = a long-chain aldehyde + H2O2 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O2 Simmondsia chinensis
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.48 seed cotyledons Simmondsia chinensis
-

Storage Stability

EC Number Storage Stability Organism
1.1.3.20 freezing overnight leads to 50% loss of activity Simmondsia chinensis
1.2.1.48 frozen, several months Simmondsia chinensis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.20 1-docosanol + O2 i.e. behenyl alcohol, poor substrate Simmondsia chinensis docosanal + H2O2
-
 ?
1.1.3.20 1-eicosanol + O2 i.e. arachidyl alcohol, poor substrate Simmondsia chinensis eicosanal + H2O2
-
 ?
1.1.3.20 1-tetradecanol + O2
-
 Simmondsia chinensis tetradecanal + H2O2
-
 ?
1.1.3.20 cis-11-eicosenol + O2 higher oxidation rate than saturated analog Simmondsia chinensis cis-11-eicosenal + H2O2
-
 ?
1.1.3.20 decanol + O2
-
 Simmondsia chinensis decanal + H2O2
-
 ?
1.1.3.20 docosenol + O2 higher oxidation rate than saturated analog Simmondsia chinensis docosenal + H2O2
-
 ?
1.1.3.20 dodecanol + O2 i.e. lauryl alcohol, preferred substrate Simmondsia chinensis dodecanal + H2O2
-
 ?
1.1.3.20 hexadecanol + O2
-
 Simmondsia chinensis hexadecanal + H2O2
-
 ?
1.1.3.20 long-chain alcohol + O2 reaction in wax ester catabolism in the storage wax bodies of jojoba plant during germination Simmondsia chinensis ?
-
 ?
1.1.3.20 long-chain alcohol + O2 monounsaturated long-chain alcohols Simmondsia chinensis ?
-
 ?
1.1.3.20 additional information no substrates: ethanol, palmitic acid Simmondsia chinensis ?
-
 ?
1.1.3.20 octadecanol + O2
-
 Simmondsia chinensis octadecanal + H2O2
-
 ?
1.2.1.48 decanal + NAD+ + H2O
-
 Simmondsia chinensis decanoic acid + NADH
-
 ?
1.2.1.48 dodecanal + NAD+ + H2O best substrate Simmondsia chinensis dodecanoic acid + NADH
-
 ?
1.2.1.48 hexadecanal + NAD+ + H2O
-
 Simmondsia chinensis hexadecanoic acid + NADH
-
 ?
1.2.1.48 long-chain aldehyde + NAD+ mobilization of intracellular wax esters in the cotyledon during germination Simmondsia chinensis ?
-
 ?
1.2.1.48 long-chain aldehyde + NAD+ + H2O
-
 Simmondsia chinensis long-chain acid anion + NADH
-
 ?
1.2.1.48 additional information not: acetaldehyde Simmondsia chinensis ?
-
 ?
1.2.1.48 tetradecanal + NAD+ + H2O
-
 Simmondsia chinensis tetradecanoic acid + NADH
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.3.20 100
-
 boiling for 30 min inactivates the enzyme Simmondsia chinensis
1.2.1.48 55
-
 30 min, 80% loss of activity Simmondsia chinensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.3.20 9
-
 1-dodecanol Simmondsia chinensis
1.2.1.48 9
-
-
 Simmondsia chinensis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.3.20 6.6 9.3 about half-maximal activity at pH 6.6 and 9.3 Simmondsia chinensis
1.2.1.48 6.5 10 pH 6.5: about 25% of activity maximum, pH 10: about 75% of activity maximum Simmondsia chinensis

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.48 NAD+ NAD+ is a much better electron acceptor than NADP+, FAD or flavin mononucleotide Simmondsia chinensis