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Literature summary extracted from

  • Nakano, M.; Ushijima, Y.; Saga, M.; Tsutsumi, Y.; Asami, H.
    Aliphatic L-alpha-hydroxyacid oxidase from rat livers. Purification and properties (1968), Biochim. Biophys. Acta, 167, 9-22.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.3.15 ascorbate 17.5-26% activation at 1 mM Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.3.15 4-chloromercuribenzoate strong inhibition at 0.01 mM Rattus sp.
1.1.3.15 8-hydroxyquinoline 8-17% inhibition at 1 mM Rattus sp.
1.1.3.15 Cu2+ complete inhibition at 0.025 mM Rattus sp.
1.1.3.15 diethyldithiocarbamate 51-55% inhibition at 1 mM Rattus sp.
1.1.3.15 KCN 30% inhibition of L-2-hydroxyisocaproate oxidation at 1 mM, 91% inhibition of glycolate oxidation at 1 mM Rattus sp.
1.1.3.15 o-Iodosobenzoate 46% inhibition at 0.1 mM Rattus sp.
1.1.3.15 o-phenanthroline 5-14% inhibition at 1 mM Rattus sp.
1.1.3.15 Quinacrine 6% inhibition at 1 mM Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.3.15 0.5
-
glycolate
-
Rattus sp.
1.1.3.15 1.34
-
DL-2-hydroxycaproate
-
Rattus sp.
1.1.3.15 1.65
-
L-2-Hydroxyisocaproate
-
Rattus sp.
1.1.3.15 8.5
-
L-lactate
-
Rattus sp.
1.1.3.15 12.7
-
DL-2-hydroxybutyrate
-
Rattus sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.3.15 300000
-
gel filtration Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.15 D-lactate + O2 Rattus sp. traces of activity pyruvate + H2O2
-
?
1.1.3.15 DL-2-hydroxybutyrate + O2 Rattus sp.
-
2-oxobutyrate + H2O2
-
?
1.1.3.15 DL-2-hydroxycaproate + O2 Rattus sp.
-
2-oxocaproate + H2O2
-
?
1.1.3.15 DL-2-hydroxyisovalerate + O2 Rattus sp. low activity 2-oxoisovalerate + H2O2
-
?
1.1.3.15 DL-2-hydroxyvalerate + O2 Rattus sp.
-
2-oxovalerate + H2O2
-
?
1.1.3.15 glycolate + O2 Rattus sp.
-
glyoxylate + H2O2
-
?
1.1.3.15 L-2-hydroxyisocaproate + O2 Rattus sp. best substrate tested 2-oxoisocaproate + H2O2
-
?
1.1.3.15 L-lactate + O2 Rattus sp.
-
pyruvate + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.15 Rattus sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.3.15 to homogeneity, chromatography steps Rattus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.15 liver
-
Rattus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.3.15 25.43
-
-
Rattus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.15 D-lactate + O2 traces of activity Rattus sp. pyruvate + H2O2
-
?
1.1.3.15 DL-2-hydroxybutyrate + O2
-
Rattus sp. 2-oxobutyrate + H2O2
-
?
1.1.3.15 DL-2-hydroxycaproate + O2
-
Rattus sp. 2-oxocaproate + H2O2
-
?
1.1.3.15 DL-2-hydroxyisovalerate + O2 low activity Rattus sp. 2-oxoisovalerate + H2O2
-
?
1.1.3.15 DL-2-hydroxyvalerate + O2
-
Rattus sp. 2-oxovalerate + H2O2
-
?
1.1.3.15 glycolate + O2
-
Rattus sp. glyoxylate + H2O2
-
?
1.1.3.15 L-2-hydroxyisocaproate + O2 best substrate tested Rattus sp. 2-oxoisocaproate + H2O2
-
?
1.1.3.15 L-lactate + O2
-
Rattus sp. pyruvate + H2O2
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.3.15 8.5
-
-
Rattus sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.3.15 0.77
-
diethyldithiocarbamate competitive Rattus sp.
1.1.3.15 0.88
-
KCN uncompetitive Rattus sp.