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Literature summary extracted from

  • Bertics, P.J.; Edman, C.F.; Karavolas, H.J.
    Potent inhibition of the hypothalamic progesterone 5alpha-reductase by a 5alpha-dihydroprogesterone analog (1984), J. Biol. Chem., 259, 107-111.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.50 4-Aza-4-methyl-5alpha-pregnane-3,20-dione only slight inhibition Rattus norvegicus
1.3.1.22 4-Aza-4-methyl-5alpha-pregnane-3,20-dione competitive against progesterone, reversible, transition state analog Rattus norvegicus
1.3.1.22 NADP+ product inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.22 0.00013
-
 progesterone
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.50 cytoplasmic membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
-
1.1.1.50 cytosol NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus 5829
-
1.1.1.50 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.50 Rattus norvegicus
-
 NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity
-
1.3.1.22 Rattus norvegicus
-
 female rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.50 hypothalamus
-
 Rattus norvegicus
-
1.3.1.22 hypothalamus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.3.1.22 progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.50 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase NADH- and NADPH-linked Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.50 NADH plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.1.1.50 NADPH cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.3.1.22 NADPH
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.22 0.0000062
-
 4-Aza-4-methyl-5alpha-pregnane-3,20-dione versus progesterone Rattus norvegicus
1.3.1.22 0.0000118
-
 4-Aza-4-methyl-5alpha-pregnane-3,20-dione versus NADPH Rattus norvegicus