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Literature summary extracted from

  • Krause, J.E.; Karavolas, H.J.
    Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH- and NADPH-linked 3alpha-hydroxysteroid oxidoreductase activities (1980), J. Steroid Biochem., 13, 271-280.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.50 cytoplasmic membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
-
1.1.1.50 cytosol NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus 5829
-
1.3.1.22 cytoplasmic membrane
-
 Rattus norvegicus
-
-
1.3.1.22 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus
-
 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.50 Rattus norvegicus
-
 NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity
-
1.3.1.22 Rattus norvegicus
-
 female rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.50 hypothalamus
-
 Rattus norvegicus
-
1.3.1.22 hypothalamus
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.50 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
 ?
1.1.1.50 5alpha-pregnan-3,20-dione + NAD(P)H + H+ 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 ?
1.1.1.50 5alpha-pregnan-3,20-dione + NADPH
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 r
1.3.1.22 progesterone + NADPH + H+
-
 Rattus norvegicus 5alpha-pregnan-3-20-dione + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.50 3alpha-hydroxysteroid oxidoreductase NADH- and NADPH-linked Rattus norvegicus
1.1.1.50 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.50 NADH plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.1.1.50 NADPH cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
1.3.1.22 NADPH
-
 Rattus norvegicus