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Literature summary extracted from
- Purification of the NADPH:5alpha-dihydroxyprogesterone 3alpha-hydroxysteroid oxidoreductase from female rat pituitary cytosol (1990), J. Steroid Biochem. Mol. Biol., 37, 215-222.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.50 | 0.000082 | - |
5alpha-pregnan-3,20-dione | reduction | Rattus norvegicus |  |
| 1.1.1.50 | 0.00071 | - |
NADPH | - |
Rattus norvegicus | |
| 1.1.1.50 | 0.0014 | - |
3alpha-hydroxy-5alpha-pregnan-20-one | oxidation | Rattus norvegicus | |
| 1.1.1.50 | 0.0016 | - |
NADP+ | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.50 | cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.50 | 36000 | - |
non-dissociating electrophoresis | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.50 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.50 | micro-purification procedure | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.50 | hypophysis | female | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.50 | 0.04 | - |
5alpha-pregnan-3,20-dione | Rattus norvegicus |
| 1.1.1.50 | 0.323 | - |
3alpha-hydroxy-5alpha-pregnan-20-one | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.50 | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
Rattus norvegicus | 17beta-hydroxy-5alpha-androstan-3-one + NADPH | - |
? | |
| 1.1.1.50 | 5alpha-pregnan-3,20-dione + NAD(P)H | - |
Rattus norvegicus | 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.50 | monomer | 1 * 36000, SDS-PAGE | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.50 | NADPH:5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.50 | NADPH | preference for | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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