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Literature summary extracted from
- Characterization of the 3alpha-hydroxysteroid dehydrogenase of dog prostate (1977), J. Steroid Biochem., 8, 719-723.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.50 | 17,21-Dihydroxy-5alpha-pregnan-3,20-dione | - |
Canis lupus familiaris |  |
| 1.1.1.50 | 17alpha-Methyl-5alpha-dihydrotestosterone | - |
Canis lupus familiaris | |
| 1.1.1.50 | 21-Hydroxy-5alpha-pregnan-3,20-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Bromo-17beta-hydroxy-5alpha-androstan-3-one | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Bromo-5alpha-androstan-3,17-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Cyano-17beta-methoxy-4-androsten-3-one | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Cyano-17beta-methoxy-5alpha-androstan-3-one | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Cyano-5alpha-dihydrotestosterone | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Fluoro-5alpha-androstan-3,17-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 2alpha-Iodo-5alpha-androstan-3,17-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5alpha-Androstan-3,16-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5alpha-androstan-3,17-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5alpha-Androstan-3-one | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5alpha-Dihydrotestosterone hemisuccinate | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5alpha-pregnan-3,20-dione | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5beta-dihydrotestosterone | - |
Canis lupus familiaris | |
| 1.1.1.50 | 5beta-pregnan-3,20-dione | - |
Canis lupus familiaris | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.50 | 0.00062 | 0.00065 | 5alpha-dihydrotestosterone | - |
Canis lupus familiaris | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.50 | cytosol | - |
Canis lupus familiaris | 5829 | - |
| 1.1.1.50 | microsome | - |
Canis lupus familiaris | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.50 | Canis lupus familiaris | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.50 | prostate gland | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.50 | 5alpha-dihydrotestosterone + NAD(P)H + H+ | i.e. 5alpha-androstan-17beta-ol-3-one | Canis lupus familiaris | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
r | |
| 1.1.1.50 | 5alpha-dihydrotestosterone + NAD(P)H + H+ | i.e. 5alpha-androstan-17beta-ol-3-one | Canis lupus familiaris | (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+ | - |
r | |
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Release 2023.1 (January 2023)
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